NOTCH3 carriers had a threefold increased risk of ischaemic stroke (OR 3.07, 95% CI: 1.81 to 5.23, p<0.001), while a 1 SD increase in ischaemic stroke PRS increased the odds by 26% (OR: 1.26, 95% CI: 1.21 to 1.32, p<0.001). Here, NOTCH3 is linked to ischemic stroke.