Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1, OMIM 604392)-LCA is a rare cause of LCA (1%–2% of cases).47 48 This gene is expressed in photoreceptors and has a role in the synthesis of cGMP phosphodiesterase, a key element in phototransduction. This evidence concerns the gene AIPL1 and Leber congenital amaurosis.