The fact that fasting hyperinsulinemia was associated with high FFA levels in presence of normal fasting glycaemia is also consistent with studies indicating that insulin controls hepatic glucose production mainly through its direct action in the hepatocyte [52,53] rather than by reducing circulating levels of FFA and glycerol driving hepatic glucose production [3,17,54,55]. The gene discussed is INS; the disease is Hyperinsulinemia.