Moreover, the general role of FFA as pathogenic drivers of insulin resistance has been questioned: data on 5790 individuals from the Paris Prospective Study and on 1591 individuals from the Oxford Biobank indicate that fasting levels of circulating FFA are not generally elevated in subjects with larger fat mass [26]; and it was reported that FFA release per 100 g of adipose tissue are downregulated in subjects with larger fat mass and negatively correlated with fasting circulating insulin levels [26]. Here, INS is linked to Insulin resistance.