Our data indicate a possible mechanistic explanation for such deranged lipolysis: the increased basal lipolysis, measured in-vitro in isolated adipocytes, can be explained by reduced levels of CIDEA, a most potent negative regulator of basal lipolysis [59], whereas reduced levels of ADRB3; GJA1 - connexin 43; and AZGP1 provide a sound mechanistic explanation for the reduced catecholamine-stimulated lipolysis observed in obesity [57,58]. The gene discussed is AZGP1; the disease is obesity due to melanocortin 4 receptor deficiency.