Deletion of ERRα/γ in mice leads to cardiomyopathy with arrested maturation of mitochondria, while ESRRA and ESRRA deletion in human PSC-CMs downregulates expression of non-cardiac genes, including those consistent with a fibroblast phenotype such as TCF21, periostin, and collagen type III [93]. This evidence concerns the gene ESRRA and cardiomyopathy.