Triple knockout of Drp1/Mfn1/Mfn2 remarkably delays the lethal effects of Drp1 deletion alone or Mfn1/Mfn1 deletion alone, exhibiting a concentric cardiac hypertrophy eventually leading to death between 3 and 6 months after tamoxifen treatment [168]. This evidence concerns the gene MFN1 and cardiac hypertrophy.