Global glucocorticoid receptor deficiency also prevents maturation of the heart in rats, with GR−/− rats having disorganized myofibrils, reduced diastolic function, and fetal edema characteristic of hydrops fetalis [82], while maternal glucocorticoid administration prior to preterm piglet delivery enhances cardiomyocyte maturation [83]. Here, NR3C1 is linked to hydrops fetalis.