BRAF and neoplasm: Furthermore, in our limited series of SP, BRAF V600E immunoexpression presented in both the proliferative ductal and squamous tumour elements, which confirmed by molecular analysis, similar to the results of Hsieh and Nakaguro [3, 5, 44], suggested the neoplastic nature of both components, and the transition of ductal epithelium to squamous epithelium seen in SP indicated this tumour may originate in the excretory ducts.