According to Lim et al. (2020), “this consequently results in a negative feedback loop wherein DUX4 activates Wnt/β-catenin signalling, which represses its own expression.” This may be the reason for the low amount of detectable DUX4 nuclei in FSHD muscle cells [80]. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.