IGFBP3 and amyotrophic lateral sclerosis: De Benedetti et al. [14] studied the effects of IL-6 on growth regulation using the neuro-specific enolase (NSE)/hIL-6 transgenic murine model, that overexpresses IL-6: NSE/hIL-6 mice have normal liver IGF-1 production, reduced levels of 3 IGFBP-3 and increased IGFBP-3 proteolysis, resulting in a marked decrease of circulating 150-kDa ternary complex, even in the presence of functional ALS.