Chronic inflammation can interfere with the function of GH-IGF-1 axis by inducing relative GH insufficiency, GH/IGF-1 resistance, downregulation of GH/IGF-1 receptors, dysregulation of IGFBPs and thus of IGF-1 bioavailability, impairment of local GH and IGF-1 signaling pathways and gene regulation [12]. This evidence concerns the gene IGF1 and inflammatory response.