IGFBP3 significantly enhanced TRAIL-induced cell death in colonic carcinoma-derived cell lines by inhibiting NF-κB activation in response to apoptotic induction [32], and Kim et al. showed that IGFBP3 enhanced etoposide-induced cell growth inhibition by blocking the NF-κB signaling pathway in gastric cancer cells [43]. This evidence concerns the gene NFKB1 and gastric cancer.