Several studies reported that IGFBP3 may have a significant role in regulating DNA repair by forming a complex with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and epidermal growth factor receptor (EGFR) in response to DNA damage in breast cancer cells and OSCC cells [21, 41], implicating a direct role of IGFBP3 in DNA repair. This evidence concerns the gene IGFBP3 and breast cancer.