Immunostaining of tumor sections with an anti-Ki-67 antibody showed reduced Ki-67 staining in IGFBP3-expressing tumor sections (n = 25; 13 ± 0.9323% per field) compared to controls after IR (n = 25; 25.95 ± 0.9992% per field; p < 0.0001; Fig. 2d). Here, IGFBP3 is linked to neoplasm.