Notably, CAR as a ratio of CRP to ALB initially proposed by Fairclough [48], has been widely demonstrated to be more valuable and accurate than either CRP or ALB alone, providing a variable capable of merging information in the prediction of the systemic inflammatory state and prognosis in adverse cardiovascular events, cancers, inflammatory bowel disease, arteritis and critically ill septic patients [32–40, 48–51]. The gene discussed is CRP; the disease is inflammatory bowel disease.