Excitingly, our data have indeed confirmed these effects: H3K4me1 and H3K27me1 bind to more IRF4/5 DNA, respectively, in female vs. male microglia (Fig. 4f, i) after OGD; however, mice with two copies of X have higher IRF5 and lower IRF4 level compared to one X mice after stroke (Fig. 4c, d). The gene discussed is IRF4; the disease is Stroke.