The result demonstrated that the biological process of cell cycle and glycolysis and several classical cancer-related pathway including PI3K/Akt/mTOR pathway, p53 pathway, Notch pathway, WNT/β-catenin pathway, TGF-β/SMAD pathway and MAPK pathway were significantly enriched in the high-risk group (Fig. 8a–e). The gene discussed is TP53; the disease is cancer.