Then, OS analysis of patients stratified by the expression levels of the 11 key genes revealed that AREG and CAV1 were associated with poor prognosis in HNSCC patients, C19orf57 and STAG3 were associated with favorable prognosis, and the other 7 genes were not significantly associated with OS (Additional file 2: Figure S2). The gene discussed is CAV1; the disease is head and neck squamous cell carcinoma.