In addition, AREG upregulated samples were enriched in the pathways of protein G-2 and S-phase expressed 1 (GTSE1) in G2/M progression after the G2 checkpoint (Fig. 8c), and associated with genes up-regulated in SCC12B2 cells (squamous cell carcinoma) by ultraviolet B (UV-B) irradiation (Fig. 8d). This evidence concerns the gene GTSE1 and squamous cell carcinoma.