INS and diabetes mellitus: The gene regulatory network controlled by transcription factor NKX6.1 is also necessary to maintain the function and identity of mature β cells [10, 11], and the overexpression of Nkx6.1 in adult mouse β cells of mice resulted in elevated glucose stimulated insulin secretion (GSIS) [10], yet the inactivation of Nkx6.1 could lead to a decrease in insulin secretion, causing diabetes [11].