High expression of ITGA5 was marginally correlated with poor prognosis in pancreatic cancer (OS HR = 1.6, P = 0.12; DFS HR = 2.1, P = 0.015) (Fig. 2a-b) and esophageal cancer (OS HR = 1.4, P = 0.37; DFS HR = 1.2, P = 0.52) (Fig. 2c-d). Here, ITGA5 is linked to familial pancreatic carcinoma.