High expression of ITGA5 was also associated with poor prognosis in lung cancer (OS HR = 1.6, 95% CI = 1.4 to 1.81, P = 5.9e-13; DFS HR = 1.75, 95% CI = 1.44 to 2.12, P = 1.2e-08) and breast cancer (OS HR = 1.21, 95% CI = 0.96 to 1.52, P = 0.11; DFS HR = 1.28, 95% CI = 1.14 to 1.44, P = 4.1e-05) (Additional file: Fig. S1). This evidence concerns the gene ITGA5 and breast carcinoma.