The E value for the association between the combination of elevated NT-proBNP with frequent SVEs and AF incidence was 5.06 with the confidence limit of 3.11, suggesting that the observed association could be removed by an unmeasured confounder, which is related to both independent and dependent variable with a relative risk of 5.06, indicating a high robustness of current results. This evidence concerns the gene NPPB and atrial fibrillation.