Other molecules on this network and known to be associated with the biogenesis, regulation and function of pancreatic β-cell insulin granules included Secretogranins SCG2 and SCG3, the Staninocalcin STC2, Chromogranin CHGB, key diabetes susceptibility gene Proprotein Convertase Subtilisin/kexin type 2 (PCSK2), the synaptotagamin SYT5 and the outward rectifying potassium channel KCNK16 (TALK1), all upregulated in the KK/HlJ strain by between 1.51 and 6.75-fold. The gene discussed is PCSK2; the disease is diabetes mellitus.