Other studies have shown that whereas βcell-targeted knockout of Nnat in male mice fed a standard chow diet did not impair fasting blood glucose levels, βcell KO-Nnat+/−p mice fed a high-energy diet exhibited elevated fasting blood glucose together with glucose intolerance compared to wildtype C57BL/6 J mice, despite no apparent effect on body weight, feeding or energy expenditure [76]. The gene discussed is NNAT; the disease is glucose measurement.