More specifically, we will investigate whether lncRNA XLOC-022175 can regulate CXCL2 secretion to recruit neutrophils to sites of PRRSV infection, whether XLOC-019295 plays a duel role in host defense against infectious diseases, and whether XLOC-017089 can modify PRRSV infection through regulating the expression of the scavenger receptor CD163. Here, CXCL2 is linked to infectious disease.