LEP and Insulin resistance: First, we carried out MR analyses to test whether 10 cardiometabolic traits related to insulin resistance (fasting insulin, triglycerides, HDL, low-density lipoprotein (LDL), fasting plasma glucose (FPG), body mass index (BMI), glucose tolerance, leptin, glycated haemoglobin (HbA1C), and T2DM) could be causally associated with schizophrenia.