First, we carried out MR analyses to test whether 10 cardiometabolic traits related to insulin resistance (fasting insulin, triglycerides, HDL, low-density lipoprotein (LDL), fasting plasma glucose (FPG), body mass index (BMI), glucose tolerance, leptin, glycated haemoglobin (HbA1C), and T2DM) could be causally associated with schizophrenia. This evidence concerns the gene INS and Insulin resistance.