Kaplan-Meier analysis showed that the following parameters were significantly associated with OS: history of smoking (P = 0.013), NSE level (P < 0.001), CEA level (P < 0.001), Cyfra21-1 level (P = 0.020), tumor size (P < 0.001), lymph node metastasis (P < 0.001), distant metastasis (P < 0.001), histologic style (P = 0.017), and TNM stage (P < 0.001). The gene discussed is ENO2; the disease is metastatic malignant neoplasm in the lymph nodes.