The CCK-8 assay results showed that pcDNA3.1-HIF1A-AS2 co-transfected si-NC accelerated renal carcinoma cell proliferation, and si-SOX4 co-transfected si-NC was reversed (P < 0.01) in 786-O and OS-RC-2 cells. Here, SOX4 is linked to renal carcinoma.