Overall, BRCA1/2 mutation carriers present an increased risk for breast cancer (BC) (52%–72% in BRCA1, 45%–84% in BRCA2), ovarian cancer (OC) (39%–63% in BRCA1, 11%–27% in BRCA2), PrC (3.4-fold increased risk in BRCA1, 8.6-fold increased risk in BRCA2), and pancreatic cancer (PC) (1%–3% in BRCA1, 2%–7% in BRCA2)7–11. The gene discussed is BRCA2; the disease is pachyonychia congenita.