In colorectal cancer (CRC), circRNA_100290 acts as an oncogene to increase metastasis and the EMT by sponging miR-516b, upregulating FZD4 expression, and then initiating the FZD4-induced Wnt/β-catenin signaling pathway40 (Figure 2F). The gene discussed is FZD4; the disease is colorectal carcinoma.