Huang et al.24 showed that circERBB2, a circRNA generated from the ERBB2 cognate gene, accumulated in the nucleus to bind with PA2G4, a nucleolus-associated protein, to regulate ribosomal DNA transcription and cell proliferation via the circERBB2-PA2G4-TIFIA axis in gallbladder cancer. This evidence concerns the gene PA2G4 and gallbladder cancer.