We found that the expression of FOXP3 and CCR4, and the percentage of CD4+FOXP3+ and FOXP3+CCR4+ Tregs chemoattracted to the tumor sites were significantly downregulated in the shL1CAM group, but upregulated in the L1CAM overexpression group, as compared with the control. This evidence concerns the gene FOXP3 and neoplasm.