We found that the expression of FOXP3 and CCR4, and the percentage of CD4+FOXP3+ and FOXP3+CCR4+ Tregs chemoattracted to the tumor sites were significantly downregulated in the shL1CAM group, but upregulated in the L1CAM overexpression group, as compared with the control. The gene discussed is CCR4; the disease is neoplasm.