To further identify the factors mediating communication between cancer and immune cells in this context, we performed cytokine array analysis with a human multiplex bead-based kit and found that CCL22 was significantly downregulated in shL1CAM cells (Figure 3C, upper panel), whereas it was significantly upregulated in L1CAM overexpressing cells at the protein level (Figure 3C, lower panel). The gene discussed is L1CAM; the disease is cancer.