Likewise, other plasma circRNAs, such as hsa_circ_0000419 and hsa_circ_0065149 in GC, circ-LDLRAD3 and circ-PDE8A in pancreatic cancer, and hsa_circ_0001946 and circ-SLC7A5 in esophageal cancer, have also been associated with clinicopathological features, malignant biological behaviors, and prognoses of cancers, and were shown to serve as prognostic indicators5,49,106,109,116,129. This evidence concerns the gene PDE8A and familial pancreatic carcinoma.