In pancreatic cancer, circ_0000977 was revealed to regulate the miR-153 downstream targets of hypoxia-inducible factor 1-alpha (HIF1A), a disintegrin, and Metalloproteinase Domain 10 to modulate HIF1A-mediated immune escape of pancreatic cancer cells from NK cells80. Here, HIF1A is linked to pancreatic neoplasm.