PDE8A and pancreatic neoplasm: Likewise, other plasma circRNAs, such as hsa_circ_0000419 and hsa_circ_0065149 in GC, circ-LDLRAD3 and circ-PDE8A in pancreatic cancer, and hsa_circ_0001946 and circ-SLC7A5 in esophageal cancer, have also been associated with clinicopathological features, malignant biological behaviors, and prognoses of cancers, and were shown to serve as prognostic indicators5,49,106,109,116,129.