FOXO3 and hepatocellular carcinoma: Similarly, in HCC, reversing the overexpression of circFBXO11 in cells significantly repressed carcinoma progression and oxaliplatin resistance by sponging miR-605, subsequently affecting the expression of FOXO3 and ABCB1, which are target genes of miR-605, suggesting that circFBXO11 has the potential to improve patient prognosis and survival134.