KLF4 and neoplasm: We found that neutralizing extracellular survivin aggravated macrophage inflammation (as measured by the expression of its associated genes), but significantly decreased the expression of genes related to immune suppression (e.g., IL-10, PPARɣ, MRC1 and KLF4), invasiveness (e.g., MMP2), tumor growth and metastasis (e.g. VIM, FN1, TGFβ1 and EGF) and TAM-specific markers (e.g., CD68) (Fig. 4b), suggesting that an autocrine survivin loop reprograms the TAM phenotype.