HIF1A and neoplasm: We found that the expression of genes related to inflammation (IL-1β, IL-6, TNFα, CCL2 and CCL3), immune suppression (IL-10, PPARɣ and KLF4), angiogenesis (HIF-1α and VEGFα), invasiveness (MMP2 and MMP9), tumor growth and metastasis (TLR2, TLR4, VIM, FN1, TGFβ1 and EGF), and TAM membrane receptors (CD14, CD11β, CX3CR1 and CD45) was significantly higher in macrophages cultured with CM-obASC than in those cultured with CM-lnASC (Fig. 1a).