Consistent with the results of the CM-obASC analysis (Fig. 1a), internalization of survivin by THP-1 macrophages was accompanied by an increase in the expression of immune regulatory genes, both pro- and anti-inflammatory (IL-1β), genes related to angiogenesis, invasiveness, tumor growth and metastasis (MMP9, TLR2, TLR4 and FN1) and to TAM membrane receptors (CD68) (Fig. 1e). This evidence concerns the gene TLR4 and neoplasm.