ERBB2 and neoplasm: HER2 is a transmembrane receptor tyrosine kinase that belongs to the HER family, and its overexpression leads to homodimerization and heterodimerization with other HER family-member proteins [2], triggering activation of the phosphoinositide-3-kinase/Akt and mitogen-activated protein kinase pathways [3], resulting in tumor proliferation, differentiation, apoptosis regulation, angiogenesis, and invasion [4].