A homozygous missense variant [p.(Cys51Tyr)] in SYPL1 (OMIM # 616,665), was found in FIN21-3 whose phenotype characterized by metopic ridge and delayed bone maturation (-4.5SD), mild ID, panic disorder, and obesity [body-mass index (BMI = 36)] (Figure S1E). The gene discussed is SYPL1; the disease is obesity due to melanocortin 4 receptor deficiency.