The increased expression of chemokines and cytokines such as Cxcl10, Ccl22, Ccl5, and Il6 in AIM2−/− cells plays a crucial role in T cell infiltration and cell proliferation during EAE (Balashov et al., 1999; Quandt and Dorovini-Zis, 2004; Takeda et al., 1998), which is critical step for the inflammation and pathogenesis of EAE or MS. This evidence concerns the gene CCL22 and myeloid sarcoma.