AIM2 and myeloid sarcoma: GSE123496, GSE26927, and GSE138614) showed that AIM2 expression is increased in the brain tissues of MS patients when compared with healthy donors (Fig. S5, C–F), suggesting that AIM2 is induced during MS and may be involved in regulating the progression of MS (Durrenberger et al., 2015; Elkjaer et al., 2019; Voskuhl et al., 2019).