In an age- and BMI-adjusted Cox proportional hazard model, HF risk was associated with elevated baseline IL-6 for those participants in the top tertile of NT-proBNP (HR 1.76 for fourth vs first IL-6 quartile, 95% CI: 1.09–2.86, p = 0.022), but not in the middle or bottom tertiles (HR 0.92, 95% CI: 0.51–1.66, p = 0.79 and HR 1.43, 95% CI: 0.59–3.5, p = 0.42, respectively). This evidence concerns the gene NPPB and hydrops fetalis.