PPARGC1A and breast cancer: We found that SDH repression inhibits proteasomal degradation of AR by upregulating p‐Hsp27 (Zoubeidi et al,2007), findings consistent with studies in breast cancer, where SDH repression can also upregulate estrogen receptor (ER) β expression (Manente et al,2013) and promote mitochondrial biogenesis via PGC1α (Chen et al,2009).