cBioPortal database analysis (Cerami et al,2012; Gao et al,2013) of different prostate adenocarcinoma studies indicates many alterations in SDHA and SDHB genes, particularly multiple shallow and deep deletions in SDHB gene (Fig EV1C,1D upper panel) as well as somatic missense and nonsense mutations in both SDHA and SDHB genes (Fig EV1D lower panel), suggesting that SDH activity can be altered in PCa. Here, SDHA is linked to posterior cortical atrophy.