LC‐MS analysis on cellular extracts also identified increased levels of lactic acid production after SDH repression, consistent with increased glycolysis; in contrast, overexpression of CII catalytic subunits (SDHA, SDHB) decreased lactic acid levels (Fig EV4A), suggesting that SDH repression post ARPI helps PCa cells adapt to energy stress by promoting glycolytic capacity. Here, SDHB is linked to posterior cortical atrophy.