These genomic alterations highlight a tumor suppressive activity of SDH subunits, where loss of SDH activity increases intracellular succinate, an oncometabolite with key roles in HIF1α stabilization, post‐translational modifications, and genome‐wide methylation (Tretter et al,2016; Bezawork‐Geleta et al,2017). Here, SDHB is linked to neoplasm.