Immunohistochemistry (IHC) staining of tissue microarrays (TMA) spotted with clinical PCa tissues demonstrated that SDHA and AR expression was significantly reduced in patients treated with neoadjuvant ADT (6 months or less), compared with those who had prostatectomy alone (Figs 5A–C and EV5A). This evidence concerns the gene SDHA and posterior cortical atrophy.