Similarly, NEPC PDX models (Lin et al,2014) with undetectable AR levels showed significantly reduced p‐Hsp27 levels (Fig EV5C and D), which could be a limiting factor for AR stabilization despite having reduced SDHA and elevated or similar p‐CaMKK2/p‐AMPK/p‐p38 axis compared with castrate‐sensitive or castrate‐resistant PCa. The gene discussed is CAMKK2; the disease is posterior cortical atrophy.