The results showed high protein expression of pro‐apoptotic factors such as Bax and BAD and lower expression of Bcl‐2 in granulosa cells of the PCOS group after treatment with the simultaneous addition of either LY294002 or MK‐2206 in combination with 0.2 mg/mL Ber, with similar values to those found in the PCOS group. The gene discussed is BAD; the disease is polycystic ovary syndrome.