TARDBP and amyotrophic lateral sclerosis: Indeed, in cultured cells, cytoplasmic TDP-43 aggregation is driven by at least two distinct pathways upon expression of inherited ALS/FTLD causative genes: RNA-binding protein-mediated LLPS promoting granular-type aggregation and histone deacelylase 6 (HDAC6)-mediated aggresome formation promoting skein-like aggregation [97].