TARDBP and amyotrophic lateral sclerosis: Intracellular TDP-43 is aggregated in a self-templating manner when the cultured cells are treated with seeds isolated from the brains of patients with ALS and FTLD-TDP, as well as synthetic peptide-derived TDP-43 CTF fibrils; this suggests that the alternate pathological TDP-43 conformations in ALS and FTLD-TDP could also arise from the prion-like properties of TDP-43 [57, 62, 103, 104].