Sequestration of TDP-43 into stress-induced NBs may be a neuroprotective strategy, because the recruitment of TDP-43 to NBs is compromised by the ALS-causing D169G mutation in RRM1, resulting in the incorporation of the mutant TDP-43 into SGs in the cytoplasm [45]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.