By investigating these RTK proteins using mutation data from the COSMIC database, we found that FLT3 and its short loop commonality RTK proteins have frequently mutated amino acid positions or mutation ‘hotspots’ in their kinase domain in various cancers (Supplementary Table S15) and in particular FLT3 is one of the most mutated genes in AML patients with a hotspot mutation (Figure 2 and Supplementary Table S10). The gene discussed is FLT3; the disease is acute myeloid leukemia.