The proteins frequently found in AML short loops include ATP-dependent RNA helicases (DDX3X, DDX17, DHX15, EIF4A1), splicing factors (U2AF2, PRPF8), heterogeneous nuclear ribonucleoproteins (HNRNPU, HNRNPK, HNRNPL, HNRNPF), paraspeckle protein (PSPC1) and ribosomal proteins (RPL6, RPS11, RPS16) (Supplementary Table S8). Here, RPL6 is linked to acute myeloid leukemia.