The proteins frequently found in AML short loops include ATP-dependent RNA helicases (DDX3X, DDX17, DHX15, EIF4A1), splicing factors (U2AF2, PRPF8), heterogeneous nuclear ribonucleoproteins (HNRNPU, HNRNPK, HNRNPL, HNRNPF), paraspeckle protein (PSPC1) and ribosomal proteins (RPL6, RPS11, RPS16) (Supplementary Table S8). The gene discussed is EIF4A1; the disease is acute myeloid leukemia.