High D-dimer levels, coagulation factor consumption, platelet consumption, and anemia along with multiple organ damage are hallmarks of DIC.40However, in our cohort high D-dimer levels did not correlate with prolonged PT, and unlike overt DIC, COVID-19 patients presented with elevated fibrinogen, FVIII activity, and FM along with D-dimer (Supplementary Fig. S7). The gene discussed is F8; the disease is anemia (phenotype).