Presence of schistocytes/RBC fragments, elevated D-dimer, and hallmarks of platelet activation and consumption correlate with a growing collective evidence of platelet-fibrin macro- and microthrombosis in the lungs and other organs of COVID-19 patients.28, 39In our cohort we demonstrate that low ADAMTS13 activity and increased schistocytes/RBC fragments on admission correlated with mortality. The gene discussed is ADAMTS13; the disease is COVID-19.