VWF and COVID-19: Many other studies have shown that despite anticoagulation, certain COVID-19 patients still thrombose.42Anticoagulation alone is not an effective treatment for DIC.44Nafamostat, a synthetic serine protease inhibitor, used to treat DIC and pancreatitis, has been shown as beneficial in COVID-19 treatment in several case reports.45Additional treatment may be required to decrease high levels of VWF antigen and activity and increase ADAMTS13 activity.