F8 and COVID-19: All these markers were even higher in intensive care unit patients and correlated with mortality.9VWF has three main functions: binding to collagen in the wounded subendothelial matrix, binding to glycoprotein-1b on platelets, and carrying then subsequently delivering coagulation factor VIII (FVIII) to the surface of activated platelets bound to wounded endothelium.10Whether the increased VWF reported in COVID-19 is a result of increased production, abnormal and/or increased release, or decreased destruction is unclear.