HSF1 and Hepatic fibrosis: For example, miR-125b promotes activation of HSCs and liver fibrosis by activating the ras homolog gene family, member A (RhoA) signaling [12], miR-26b-5p inhibits liver fibrogenesis by targeting platelet derived growth factor receptor-β (PDGFR-β) [13], and miR-455-3p alleviates HSC activation and prevents liver fibrosis by suppressing heat shock factor 1 (HSF1) expression [14].