It has been reported that PAK2 is highly expressed in activated HSCs [19], the immunohistochemical staining showed that PAK2 was positively expressed in hepatic portal area and sinuses of hepatic stromal cells (Figure 5(c), combined with immunofluorescence staining, and the results may indicate that PAK2 was positively expressed in activated HSCs in liver fibrosis. This evidence concerns the gene PAK2 and Hepatic fibrosis.