Tahmouresi et al. (2020) suggests that MANCR is a potential diagnostic biomarker for breast carcinoma (BC) and is associated with aggressive clinical parameters of BC. The study also shows that MANCR was functionally associated with cell proliferation, viability, and genomic stability and represented a potential therapeutic target for BC (Tracy et al., 2018). It is well known that the P53 pathway is related to the metabolism of cancer cells in multiple cancers (Chen et al., 2017; Goyal et al., 2019), and GSVA results also suggest that the P53 pathway was activated in high-risk OS patients. This evidence concerns the gene MANCR and breast cancer.