OSTM1 and neuropathy: Dominant CLCN7 mutations, which may lead to subcellular mislocalization of the ClC-7/Ostm1 complex or the impingement of the dysfunctional subunit on the ion transport properties of the unaffected subunit (Schulz et al., 2010; Ludwig et al., 2013), do not lead to neuropathy in mild ADO2.