CLCN7 and osteopetrosis: Clcn7unc/unc mice, in which ClC-7 functions as a pure Cl− conductor due to the E245A mutation of its “gating glutamate” did not display a fur color phenotype and they presented an osteopetrosis that was milder than in Clcn7−/− mice (Weinert et al., 2010).