CLCN7 and osteopetrosis: A mouse model recapitulating the most common ClC-7 mutation in ADO2, G215R (G213R in mouse), which was reported to impinge on subcellular trafficking (Schulz et al., 2010), developed a late-onset osteopetrosis as expected for heterozygous animals while homozygous mice displayed a phenotype similar to that of Clcn7−/− mice with death after only a few weeks and neurodegeneration (Alam et al., 2014) (Table 2).