CLCN7 and osteopetrosis: However, in contrast to Clcn7unc/unc mice, the osteopetrosis of Clcn7td/td mice was as pronounced as in Clcn7−/− mice, but intriguingly their neuropathy with lysosomal storage and neurodegeneration was less severe and no accumulation of autophagic material was detected (Weinert et al., 2014).