ETV6 and acute lymphoblastic leukemia: IGF2BP1 mRNA expression was significantly higher in ETV6-RUNX1 positive B-ALL (n = 37), (median value = 2.74) compared to the negative samples (n = 106), (median value = 0.0022) (p < 0.0001, > 1,000 fold overexpression) (Figure 3A).