Some studies suggested several shared risk factors, such as aging, obesity, and chronic inflammation, implicated in the plausible mechanisms of the association between HTN and OA, and there are also several reports that the proinflammatory cytokine interleukin-6 has a vital role in HTN and knee OA [11, 24–28]. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.