In the present study, we documented immunomodulatory mechanisms of GSYJ that relieve asthma symptoms, including AHR, lung inflammatory cell infiltration, and increased serum total IgE levels by regulating the expression of IL-5, IL-6, IFN-γ, IL-12, IL-1β, RANTES, and iNOS. The gene discussed is IGHE; the disease is asthma.