The nine key genes are composed of ANLN, BIRC5, BUB1B, CDC20, CDCA5, CDK1, NCAPG, NEK2, and TOP2A. They have been shown to be oncogenes, mainly enriched in cell division and cell cycle pathways, and capable of influencing HCC progression and prognosis. The gene discussed is NEK2; the disease is hepatocellular carcinoma.