Moreover, genome-wide DNA methylation alteration in the format of CmCGG was significantly related to the immune response to S. aureus-induced mastitis, and several genes including IL-6R, TNF, BTK, IL-1R2, and TNFSF8 were identified as potential epigenetic markers of S. aureus mastitis (Wang et al., 2020c). This evidence concerns the gene TNF and mastitis.