TNF and Parkinson disease: Also, in line with the observation that FLB internalization by microglia is accompanied by an increase in TNF-α and TGF-β production (69), MDG548, a neuroprotective PPARγ agonist used for experimental Parkinson's Disease treatment was found to increase FLB engulfment, while decreasing TNFα levels, thus providing a possible basis for PPARγ agonists protective role (101).