CGAS and Aicardi-Goutieres syndrome: This includes inflammatory syndromes such as STING-associated vasculopathy with onset in infancy (SAVI), Aicardi–Goutières syndrome (AGS), and familial chilblain lupus (19–23), but also cGAS related genetic disorders such as TREX1 associated lupus-like autoimmune disorder (24) or Bloom syndrome (19).