The arthritic joints from arthritic B6N mice revealed prominent synovial hyperplasia, inflammatory cells infiltration and cartilage and bone destruction in both group of mice immunized with native COMP+CFA or native COMP + IFA + 0.5 mg/ml M.T. at the end time point of the experiment, similarly to human RA (Figure 1C). The gene discussed is COMP; the disease is rheumatoid arthritis.