CD47 and neoplasm: Investigating these findings, Shi et al. demonstrated that Bifidobacterium accumulated inside colon cancer tumors and stimulated type I interferon signaling in a STING (stimulator of interferon genes) dependent fashion to improve cross priming of antigens inside dendritic cells, which in turn facilitated CD47 blockade dependent immune response (200). T cell immunoglobulin and mucin domain-containing protein-3 (Tim-3) blockade is another approach for anti-cancer immunotherapy which aims at alleviating T cell exhaustion and regulatory T cells in the TME to boost anti-tumor immunity.