Increased anti- PD-1 efficacy along with higher IFN-γ+ PD-1highCD103− CD8+ T cells, GrB+IFNγ+ CD8 T cells and MHCII+CD11c+ DCsToxicity: Colonization with 11-mix was also able to decrease colitis upon treatment with PD-1 or CTLA4 therapy. This evidence concerns the gene CD8A and colitis.