CD274 and cancer: Elucidating the connection between microbes and efficacy of ICB therapy, Routy et al. (12) who observed that in a cohort of 249 cancer patients [advanced NSCLC (n = 140), RCC (n = 67), or urothelial carcinoma (n = 42)], who received PD-1/PD-L1 mAb, antibiotic therapy was associated with significantly decreased overall survival and disease free survival.