FOXP3 and metastatic melanoma: Using models of metastatic melanoma, Noci et al. showed that commensal-induced Foxp3+ Tregs could lead to increased metastatic tumor growth in the lungs and modulation of the local pulmonary microbiota using aerosolized vancomycin or neomycin downregulated IL-10 producing Foxp3+ Tregs population, which led to increased T cell and NK T cell infiltration as well as reduced metastatic nodules (30).