Towards delineating the mechanism, Chen et al. determined the role of Siglec-G in attenuating DAMP-mediated inflammatory responses in sepsis, while Li et al. demonstrated that after LPS challenge, Siglec-G−/− mice produced less IL-6 and TNFα, more IL-10, and had an improved survival rate compared to Siglec-G+/− mice. This evidence concerns the gene TNF and Sepsis.