Although different anti-Hsp autoantibodies were reported to be elevated in the blood of patients suffering from numerous inflammatory and autoimmune diseases, including rheumatoid arthritis, dermatitis herpetiformis, coeliac disease, and psoriasis, their pathological role and value for prediction of the development of autoimmunity is still obscure (7, 13, 24, 25). This evidence concerns the gene HSP90B2P and rheumatoid arthritis.