HCA2 ligands have been also reported to attenuate inflammation in neurodegenerative diseases such as Parkinson's disease (115), Huntington's disease (38), Alzheimer's disease (116), multiple sclerosis (37), ischemic stroke (117) and traumatic brain injury (118), although, the mechanisms behind many of these beneficial effects have yet to be fully elucidated. The gene discussed is HCAR2; the disease is neurodegenerative disease.