In accordance with this, niacin administration attenuates iodoacetamide-induced colitis by a reduction in colon weight and colonic myeloperoxidase activity (a hallmark of colonic inflammation), and restores normal levels of colonic IL-10, tumor necrosis factor alpha (TNF-α), angiostatin and endostatin in a rat model (106). The gene discussed is IL10; the disease is colitis.