IL-1β was observed with a significant decrease in the supernatant of SFTSV infected NLRP3 KO THP-1 cells 48 h after infection compared with the wild type THP-1 cells, while no significant change of TNF-α and IL-6 was detected in the NLRP3 KO cells compared with wild type cells (Figures 4G–I). The gene discussed is IL1B; the disease is infection.